• Doxycycline is a bacteriostatic agent that acts by interfering with the bacterial protein synthesis of sensitive species.
• Doxycycline is a semi-synthetic tetracycline derived from oxytetracycline. • It acts on the subunit 30S of the bacterial ribosome, to which it is linked reversibly, blocking the union between aminoacyl-tRNA (transfer RNA) to the mRNA-ribosome complex, preventing the addition of new aminoacids into the growing peptide chain and thus
interfering with protein synthesis.
• Doxycycline is active against Gram-positive and Gram-negative bacteria.
• Spectrum of activity:
• Streptococcus spp.
• Staphylococcus aureus
• Chlamydia spp.
• Mycoplasma spp.
• Salmonella spp.
• Pasteurella multocida
• Bordetella bronchiseptica
Indications:
• Chickens (broilers): Prevention and treatment of chronic respiratory disease (CRD) and mycoplasmosis caused by microorganisms sensitive to doxycycline.
• Pigs: Prevention of clinical respiratory disease due to Pasteurella multocida and Mycoplasma hyopneumoniae sensitive to doxycycline.
• The presence of the disease in the herd should be established before treatment.
Contra Indications:
• Do not use in case of hypersensitivity to tetracyclines.
• Do not use in animals with hepatic dysfunction.
• Do not administer to laying birds four weeks before the start of lay and during lay.
• Do not use during pregnancy or lactation.
Side Effects:
• Allergic and photosensitivity reactions can occur. Intestinal flora may be affected if treatment is very prolonged, and this may result in digestive disturbance.
Dosage:
For oral administration:
Calves, goats and sheep:
• Twice daily 5 ml per 75 - 150 kg body weight for 3 - 5 days.
Poultry:
• 100 ml per 300 - 400 litres of drinking water for 3 - 5 days.
Swine:
• 100 ml per 200 - 600 litres of drinking water for 3 - 5 days.
Withdrawal Times:
• For meat: 7 days.
• Eggs: Not permitted for use in laying birds producing eggs for human consumption.
