• Tilmicosin is a broad-spectrum semi-synthetic bactericidal macrolide antibiotic synthesized from tylosin.
• It has an antibacterial spectrum that is predominantly effective against Mycoplasma, Pasteurella and Haemophilus spp. and various Gram-positive organisms such as Corynebacterium spp.
• It is believed to affect bacterial protein synthesis through binding to 50S ribosomal subunits.
• Cross-resistance between tilmicosin and other macrolide antibiotics has been observed.
• Following oral administration, tilmicosin is excreted mainly via the bile into the faeces, with a small proportion being excreted via the urine.
Indications:
• For treatment of poultry respiratory infections due to Mycoplasmas, Pasteurella multocida, Ornithobacterium rhinotracheale and many gram positive
/gram negative bacteria
• MYCO-SIN is one of the best drugs against Mycoplasmas that is easily dissolved in water and does not create problems
like pipes clogging, unsolubility in hard water and incompatibility with salts in water.
• It can be used with all drugs including coccidiostats and in all
environmental conditions including PH, salts, water salinity.
• It is very stable, and after opening of bottles keeps its efficacy for 3 months and in drinking
water for up to 4 days.
• It has high safety margin and does not cause damage if used for 5 days even with 5 times higher than its therapeutic dose
in water of broilers.
Contra Indications:
• Hypersensitivity or resistance to tilmicosin.
• Concurrent administration of other macrolides or lincosamides.
• Administration to animals with an active microbial digestion or to equine or caprine species.
• Parenteral administration, especially in porcine species.
• Administration to poultry producing eggs for human consumption or to animals intended for breeding purposes.
• During pregnancy and lactation, use only after a risk/benefit assessment by a veterinarian.
Side Effects:
• Occasionally, a transient reduction in water or (artificial) milk intake has been observed upon treatment with Tilmicosin.
Dosage:
For oral administration:
1- First time usage is during first week and preferably first 3 days of chick’s life, for 3 days.
2 – Second time is for 1-3 days, preferably 2 days after vaccination during third week of chicken’s life
, this way MYCO-SIN can stops Mycoplasma growth and protect birds during rearing period.
3 – In replacement pullets the third time of use is 3 – 4 weeks after second MYCO-SIN usage, it will be used
for 1- 2 days. If this method is not observed, it will be necessary to use MYCO-SIN minimum for 3 days
after appearance of CRD symptoms and before it is complicated with E. coli.
- Practically, for treatment, 300 ml is used in 600 liters of drinking water (75 ppm) during 3 – 5 days.
- Otherwise based on body weight, use following formula: 20 mg/kg/day, it is better to prepare
solution in water every day for same day use.
Withdrawal Times:
12 days in broilers, do not use MYCO-SIN in layers that produce table eggs.
